Genesis Plus GX is a Sega system emulator originally for the Nintendo GameCube and Nintendo Wii developed by eke-eke. The author claims the emulator has accurate emulation and 100% compatibility with Genesis/Mega Drive, Sega/Mega-CD, Sega Master System, Sega Game Gear, and SG-1000 games. It also has preliminary Pico emulation. The emulator was originally based off of Charles MacDonald's Genesis Plus 1.2a. For Mega-CD games, ISO + WAV, BIN + CUE and ISO + OGG formats are supported; ISO + MP3 is not supported.
Genesis Plus GX is also available for a variety of systems as an emulation core of the RetroArch gaming platform.
Several systems supported by this emulator have cheat code support, including Mega-CD. Gens Hacking Version is capable of creating Mega-CD PAR codes but cannot use them. Using them has no effect in-game. Codes created on Gens Hacking Version can be used in this emulator. Gens/GS is a PC emulator that also supports Mega-CD cheat codes, but only for the main 68000 address space.