From Sega Retro
I've played Sonic 1 (standalone cartridge version) on my Nomad, and I've never experienced any issues with it, other than the system occasionally crashing due to the cartridge being shaken. I've seen this list floating around, but have never seen an actual source for it.
Other than 6-button compatibility (which should be worked around by holding the Mode button, assuming it's fully-compatible with standard 6-button controllers), I don't see why any games would have issues. ---GerbilSoft (talk) 17:17, 31 August 2015 (CDT)