Genecyst
From Sega Retro
Genecyst was a popular Sega Genesis] emulator for DOS by Bloodlust Software (the same team that made Nesticle). Until the release of Gens, it was widely regarded to be the best Genesis/Megadrive emulator with the nearest competitor being KGen.
Since Gens appeared with many features such as Sega CD emulation, as well as having a Microsoft Windows-based GUI, Genecyst has been left on the shelf. It is still remarkably fast on older CPUs, however.
The emulator is no longer updated.