It is part of Sunsoft's Hebereke series - a franchise which started with the NES platform game Hebereke (known as U-four-ia: The Saga outside of Japan). Hebereke's Popoitto features characters from the game in a setting similar to Nintendo's Dr. Mario, the major difference being that here, your "targets" move.
The game was not released in the US, but curiously did see a release in Europe despite its Japanese style.
Also known as
Popoitto Hebereke (ポポイっとへべれけ)
Character Voices: Megumi Hayashibara, Mika Kanai, Norio Wakamoto, Shigeru Chiba