A Beretta M92FS heavily customised by Robert Kendo for STARS officers, nicknamed "Samurai Edge". Weak but ammo is plentiful. Can fire enhanced rounds which cause more damage but at the cost of lower fire rate.
Benelli M3 Super 90. Powerful shotgun which can cause head shots if fired upwards from point blank range. Limited range. Can be acquired at the early game inside a basement near an intersection. Can fire enchanced shotgun rounds with greater firepower at the cost of lower fire rate. Ammo is somewhat uncommon but not rare. Mikhail carries this during the Mercenaries mode.
A special handgun whose parts can be acquired from Nemesis during your first and second encounter with him. Fires much faster than Samurai Edge and can cause random critical hits but cannot fire enchanced handgun rounds. Carlos carries this during the Mercenaries mode.
Western Custom M37
A sawn-off shotgun with unique level action pattern. Similar to STI, its parts can be acquired from Nemesis during your fourth and fifth encounter. Fires somewhat faster and more powerful but has even lower range and cannot use enhanced shotgun rounds. (Trivia: Developers appearently tried to make the gun look like Winchester 1887, the famous shotgun from Terminator 2 but model and firing animation makes it look like another level action rifle not a shotgun)
A fictional grenade launcher which, similar to Bazooka from the first game and the one from second game fires different types of ammunition. Cluster rounds, Acid Rounds, Flame Rounds and newly introduced Freeze Rounds. Cluster rounds are weaker but can hit multiple enemies. Acid rounds are lethal against Hunters and other humanoid enemies. Flame rounds are lethal against plants and most regular enemies. Freeze rounds can only be produced using reloading tool and very powerful against most enemies, including Nemesis. (Warning: Nemesis can occasionally evade grenade rounds)
A S&W Model 629 Classic revolver which fires .44 caliber bullets. Can be found either in the STARS Office or in the Power Station. A very powerful weapon which can kill most enemies with a single shot and cause serious damage to Nemesis and other bosses. Ammo is very, VERY rare however. (Can only be found twice in the entire game) Can be made using reloading tool but requires an expensive gunpower formula. Save it for Nemo. Mikhail carries this during the Mercenaries mode.
This fictional weapon fires small homing missiles which stick to enemies and explode after a while damaging everyone around them. (Including you if you are close enough) Use against more powerful enemies while keeping your distance. Not too useful against Nemesis considering how quickly he can run towards you. Reloading this weapon while rounds are "pinging" will cause fired missiles to dissappear.
Sig PRO 2009. Carlos uses this during his segment in the Hospital. It is identical to Jill's handgun in every aspect.
M4A1 Carbine. Jill starts with this in her inventory if game is played in easy mode or can be acquired near the end of the game, in the Dead Factory. Uses percentage system similar to the MAC-11 from the Resident Evil 2. Fires rapidly but shots are weaker from the pistols despite being an assault rifle. Carlos carries this during his visit to hospital and during the Mercenaries mode.
Same weapon from Resident Evil 2. Can be unlocked for the main game if bought from the Mercenary mode.
Same M202 FLASH from the first game, incorrectly called M66. Can be used during the final part of the game. Can be unlocked for the game if bought from Mercenaries mode. Mikhail carries an 8-rounds version in the Mercenaries mode.
A new addition to the series, reloading tool can create different types of ammunition when combined with different gunpowders.